Prolonged Exposure to Nephritogenic Beta-Hemolytic Streptococcus in Intraperitoneal Diffusion Chambers.

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Abstract
Summary Diffusion chambers containing beta-hemolytic streptococci, nephritogenic in man, implanted in the peritoneal cavity of rats and rabbits for intervals ranging from 2 to 42 days did not produce definite glomerular lesions and, in particular, the lesion characteristic of glomerulonephritis. Tubular damage was noted in all animals. These results are somewhat at variance with previous reports of experiments performed with rats and mice(1,2,5) but similar to the results of others using mice (3,4,9), The authors gratefully acknowledge the help of Prof. G. C. McMillan for review of the pathological sections, and Dr. B. H. Matheson for evaluation of the bacteriological studies.