Loss of STAT1 expression confers resistance to IFN‐γ‐induced apoptosis in ME180 cells
- 12 October 1999
- journal article
- Published by Wiley in FEBS Letters
- Vol. 459 (3) , 323-326
- https://doi.org/10.1016/s0014-5793(99)01283-1
Abstract
Interferon gamma (IFN-γ) induces apoptosis in many tumor cell lines and sensitizes tumor cells to apoptosis by tumor necrosis factor family members. IFN-γ induces the expression of many early response genes such as interferon regulatory factor-1 (IRF-1) by activation of signal transducer and activator of transcription (STAT) factor proteins. We found that ME180 cells became resistant to IFN-γ-induced cell death after 4–5 passages in culture. These resistant cells were characterized by a loss of STAT1 expression and a loss of inducible IRF-1 expression. We describe for the first time the emergence of a STAT1-deficient ME180 cell line.Keywords
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