DNA synthesis without mitosis in amputated denervated forelimbs of larval axolotls

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Abstract
Both forelimbs of axolotl larvae were amputated at the elbow and left limbs were immediately denervated. Both the left and right limbs of 4 larvae/day were examined for DNA synthesis (H3‐thymidine‐autoradiography) and mitotic index on days 1 to 7 post‐amputation. DNA synthesis was evident in both innervated regenerating, and denervated non‐regenerating limb stumps, on days 4, 5, 6, and 7. Mitotic index increased only in innervated limbs, beginning on day 5.