Symposium on Androgen Action in Prostate Cancer

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Abstract
Many key aspects of the highly complex, yet poorly understood, functions of androgen receptor in prostate cancer were reviewed and analyzed. Dr. John Isaacs (Johns Hopkins University, Baltimore, MD) presented evidence that the androgen receptor serves as a switch from a paracrine growth mechanism in normal prostate epithelium to an autocrine growth mechanism in prostate cancer. Androgens suppress growth and promote differentiation in normal cells and stimulate growth in cancer cells. Also, expression levels of androgen receptor vary with the cell cycle. Symposium participants were presented the interesting concept that the androgen receptor is a tumor suppressor in normal prostate epithelium and an oncogene in prostate cancer.

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