Indications That the Cγ2 Homology Region Is Not a Regular Domain

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Abstract
The Cγ2 homology region of rabbit IgG does not behave like a domain. Thus, there is no trans‐interaction between the two Cγ2 regions: instead there is an unusual cis‐interaction between Cγ2 and Cγ3 regions. The observations were made on the plasmin digestion products Facb (IgG minus the Cγ3 region) and pFc’(Cγ3 region), which did not dissociate under neutral conditions but dissociated in 3M guanidine solution (that is. cis‐interaction between Cγ2 and Cγ3). The Facb fragment split into subunits with equal molecular weights under neutral conditions on partial reduction and alkylation (that is, lack of transinteraction between the two Cγ2 in the molecule).