The glycine‐rich loop of adenylate kinase forms a giant anion hole
- 2 November 1986
- journal article
- research article
- Published by Wiley in FEBS Letters
- Vol. 208 (2) , 301-304
- https://doi.org/10.1016/0014-5793(86)81037-7
Abstract
The conformation of the glycine‐rich loop of adenylate kinase is described in detail. It forms a giant anion hole for a sulfate ion, which presumably mimicks a nucleotide phosphoryl group. This loop had been called flexible, because at pH values of 6 or below it is displaced in the crystal. In the region of this loop the adenylate kinases are probably homologous to the p21 proteins. Is is known that a mutation in this loop at residue 12 of p21 causes cell transformation and therefore cancer. Other potentially homologous proteins are indicated.Keywords
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