Iontophoresis of Vidarabine Monophosphate for Herpes Orolabialis
- 1 December 1986
- journal article
- clinical trial
- Published by Oxford University Press (OUP) in The Journal of Infectious Diseases
- Vol. 154 (6) , 930-934
- https://doi.org/10.1093/infdis/154.6.930
Abstract
The cutaneous application of antiviral agents was studied by iontophoresis, a process that increases penetration of most drugs 20- to 60-fold. Twenty-seven subjects with vesicular orolabial herpes were treated one time in a double-blind, placebo-controlled clinical study: nine received vidarabine monophosphate (ara-AMP), nine received acyclovir (ACV), and nine received NaCl. Ara-AMP-treated lesions yielded lower titers of virus after 24 hr compared with lesions treated with NaCI or ACV (P < .05). Ara-AMP significantly decreased the duration of shedding of virus (P < .05) and time to dry crust (P < .05) compared with the other two agents. There was a trend toward decreased healing time after araAMP treatment.Keywords
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