Structural Insight into Processive Human Mitochondrial DNA Synthesis and Disease-Related Polymerase Mutations
- 1 October 2009
- Vol. 139 (2) , 312-324
- https://doi.org/10.1016/j.cell.2009.07.050
Abstract
No abstract availableKeywords
Funding Information
- Welch Foundation (F-1592)
- Argonne National Laboratory
- National Institutes of Health (GM083703)
- U.S. Department of Energy (DE-AC02-06CH11357)
This publication has 50 references indexed in Scilit:
- Structural Basis for DNA-Hairpin Promoter Recognition by the Bacteriophage N4 Virion RNA PolymeraseMolecular Cell, 2008
- The EM structure of human DNA polymerase γ reveals a localized contact between the catalytic and accessory subunitsThe EMBO Journal, 2007
- The accessory subunit B of DNA polymerase is required for mitochondrial replisome functionNucleic Acids Research, 2007
- Modulation of the W748S mutation in DNA polymerase γ by the E1143G polymorphismin mitochondrial disordersHuman Molecular Genetics, 2006
- Mutant POLG2 Disrupts DNA Polymerase γ Subunits and Causes Progressive External OphthalmoplegiaAmerican Journal of Human Genetics, 2006
- A Novel Processive Mechanism for DNA Synthesis Revealed by Structure, Modeling and Mutagenesis of the Accessory Subunit of Human Mitochondrial DNA PolymeraseJournal of Molecular Biology, 2006
- A Mitochondrial Paradigm of Metabolic and Degenerative Diseases, Aging, and Cancer: A Dawn for Evolutionary MedicineAnnual Review of Genetics, 2005
- Structural Determinants in Human DNA Polymerase γ Account for Mitochondrial Toxicity from Nucleoside AnalogsJournal of Molecular Biology, 2003
- [20] Processing of X-ray diffraction data collected in oscillation modePublished by Elsevier ,1997
- The CCP4 suite: programs for protein crystallographyActa Crystallographica Section D-Biological Crystallography, 1994