False-positive results with chemically modified anti-D
- 1 March 1987
- journal article
- research article
- Published by Wiley in Transfusion
- Vol. 27 (2) , 142-144
- https://doi.org/10.1046/j.1537-2995.1987.27287150185.x
Abstract
Chemically modified anti-D typing serum is considered to combine the reliability of saline IgM anti-D with the convenience of slide and rapid tube anti-D. This has led to its wide acceptance in modern blood bank practice. False-positives are considered rare and are controlled by the ABO grouping. The extra step of an Rh control, which is necessary with IgG slide and rapid tube anti-D serums, is thus eliminated. However, this report shows that adopting this practice can be misleading and dangerous. Two cases are reviewed in which the chemically modified anti-D gave false-positive results and the ABO typing did not act as an adequate control.This publication has 2 references indexed in Scilit:
- Spontaneous agglutination of red cells with a positive direct antiglobulin test in various mediaTransfusion, 1984
- Conversion of incomplete antibodies to direct agglutinins by mild reduction: evidence for segmental flexibility within the Fc fragment of immunoglobulin G.Proceedings of the National Academy of Sciences, 1977