A Possible Role of γA-Immunoglobulin in Herpes Simplex Virus Infection in Man

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Abstract
Summary: The capacities to synthesize γA in normal subjects and persons with primary and recurrent herpetic infections were analyzed and compared. Complications of primary infections and recurrences appeared to be associated with a deficiency of herpes-specific γA. The threshold protective titer of this γA appeared to be 12 to 20. The initial immune response to herpes infection was characterized by a marked increase in the γM titer, followed after 21 days by a predominance of γA and γG. The protective effect of γA in the mucocutaneous tissues appears to be associated with its high avidity for the herpes simplex virus and its active secretion by such tissues.