Correlation between food intake and CSF IL-1α in anorectic tumor bearing rats

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Abstract
POSTULATING that central IL-1 is involved in the pathogenesis of cancer anorexia we measured IL-1α in cerebrospinal fluid (CSF) from anorectic tumor bearing (TB) rats and non-tumor bearing controls, and correlated their CSF IL-1α with food intake and tumor weight. Food intake in controls was significantly higher than that in anorectic TB rats. Eight of the 13 anorectic TB rats had detectable CSF IL-1α; no CSF IL-1α was detected in controls. In anorectic TB rats a negative correlation existed between CSF IL-1α and food intake and a positive correlation between CSF IL-1α and tumor weight. Data suggest a link between CSF IL-1α and the pathogenesis of cancer anorexia.

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