Response of the Pocket Mouse to Ionizing Radiation

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Abstract
Two species of pocket mice, Perognathus longimembris and P. formosus, were given single doses of whole-body X- and gamma -radia-tion of 400, 600, 800, 1000, 1200, 1400, 1600, 1800, and 2000 r. Dose levels above 1200 r resulted in significant numbers of acute deaths. The LD50(30) value for P. formosus was 1300 r and that for P. longi-membris was 1520 r. Postirradiation hematological changes in the pocket mouse were similar to those of other mammals but much larger radiation doses were needed to produce changes of comparable magnitude. Several possible explanations are offered for this high degree of natural radiation resistance in the pocket mouse.

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