In vitro-Untersuchungen über die Wirkung von gelöstem und ungelöstem heterologen Collagen-Vlies auf menschliche Thrombozyten

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Abstract
Hemostasis in bone-bleeding is difficult. Local hemostatics are often used. Xenolog collagen-sponge in bone defects, was combined with synthetic apatite to achieve additional osteoinduction. The mechanism of hemostasis by collagen-sponge is examined. A detailed discussion of in vitro experiments with xenolog collagen-sponge and dissolved collagen-sponge are reported. While native collagen is an important natural hemostatic agent, this collagen-specific effect is not observed in these experiments, neither in platelets nor in endoplasmatic hemostasis. Regarding clinical experiences physical effects must be considered as mechanism of hemostasis by xenolog collagen-sponge.

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