Synthesis of 6-O-Mycoloyl-Nacetylmuramyl-l-alanyl-d-isoglutamine with Antitumor Activity
- 1 November 1978
- journal article
- Published by Oxford University Press (OUP) in Bulletin of the Chemical Society of Japan
- Vol. 51 (11) , 3307-3311
- https://doi.org/10.1246/bcsj.51.3307
Abstract
N-Acetylmuramyl-l-alanyl-d-isoglutamine corresponding to the minimum structure responsible for the immunoadjuvant activity of bacterial cell walls was acylated at the 6-hydroxyl group with various mycolic acids of long carbon chains in order to test their possible antitumor effects. Mycolic acids used were extracted from cell walls of Mycobacterium, Nocardia, and Corynebacterium. All the mycoloyl derivatives synthesized show antitumor activity based on a principle of immunotherapy.This publication has 5 references indexed in Scilit:
- Synthesis of 6-O-Acyl Derivatives of Immunoadjuvant Active N-Acetylmuramyl-l-alanyl-d-isoglutamineBulletin of the Chemical Society of Japan, 1978
- Chemical Synthesis of N-Acetylmuramyl Peptides with Partial Structures of Bacterial Cell Wall and Their Analogs in Relation to Immunoadjuvant ActivitiesBulletin of the Chemical Society of Japan, 1976
- A New Procedure for the Pentachlorophenylation of N-Protected Amino AcidsCHEMICAL & PHARMACEUTICAL BULLETIN, 1968