Excretion of Aflatoxin by Frogs After Implantation with Aspergillus flavus

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Abstract
Fluorescent entities with the chromatographic properties of the two major aflatoxins were excreted by frogs that had implants of mycelial mats of Aspergillus flavus. The amount excreted by control animals bearing autoclaved implants was less than 50% of that excreted by frogs bearing viable implants. The ratios of aflatoxin B to G in the excretions of frogs bearing viable mats underwent pronounced shifts that did not occur in the ratios of excretions from the control groups. The injection of glucose uniformly labelled with 14C into frogs bearing implanted viable mycelia permitted the recovery of radioactive aflatoxin from the urine and feces. The identity of the excreted material was established in confirmatory tests. These findings suggest that A. flavus retains the ability to produce aflatoxin during simulated aspergillosis in frogs.