Specific antibody-dependent binding of complement component C1q to hapten-sensitized lipid vesicles.
- 1 March 1978
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 75 (3) , 1515-1518
- https://doi.org/10.1073/pnas.75.3.1515
Abstract
The binding of a component of human complement (Clq) to membrane-bound specific anti-nitroxide antibodies was studied as a function of the physical properties (fluid vs. solid) of vesicle lipids. The antibodies were bound to spin-label lipid haptens in the vesicle membrane. The binding of Clq to the sensitized vesicles shows a maximum as a function of specific Ig[immunoglobulin]G concentration. The binding of antibodies and of Clq to the vesicle membrane does not depend strongly on the physical state of the membrane lipids, even at low hapten (0.05 mol %) concentrations. These results are of significance for the understanding of the effect of lipid physical states on complement depletion.This publication has 17 references indexed in Scilit:
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