Improved procedure for Juliá–Colonna asymmetric epoxidation of α,β-unsaturated ketones: total synthesis of diltiazem and Taxol TM side-chain
- 1 January 1997
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- No. 23,p. 3501-3508
- https://doi.org/10.1039/a704413e
Abstract
Poly-L-leucine catalyses the asymmetric epoxidation of enones 1–6 efficiently in a non-aqueous medium to provide the epoxy ketones 7–12 (70–91% yield; 80 to 95% ee). The strategy was used to make diltiazem 16 and the Taxol TM side chain 23 in single enantiomer form.Keywords
This publication has 0 references indexed in Scilit: