SONIC FRAGILITY OF LEUKOCYTES FROM GUINEA PIGS VACCINATED WITH BCG

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Abstract
Immune monocytes obtained from guinea pigs vaccinated with heat-killed tubercle bacilli and suspended in immune serum were more resistant to disruption by sonic vibration than similar cells in normal serum. Suspending normal cells in immune serum did not increase their resistance to sonic disruption. When thoroughly washed immune monocytes were suspended in normal serum and incubated for 6 hours, a factor was released into the serum capable of protecting normal monocytes against sonic disruption and of rendering normal monocytes susceptible to lysis by PPD (purified protein derivative).