Abstract
CSF/plasma concentration quotients for Ig G (I) and albumin (A) were determined in guinea pigs. Age and sex-dependent influences on these quotients (I/A) were analyzed and compared with the values for human lumbar, cisternal and ventricular CSF. The ratio I/A, which characterizes the molecular size-dependent selectivity of the blood CSF barrier function for proteins, was a constant in a single species, but showed marked interspecies differences.

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