Pemphigus — Decoding the Cellular Language of Cutaneous Autoimmunity

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Abstract
The primary causes of the most common autoimmune disorders have been elusive. Pemphigus foliaceus has attracted considerable attention, despite its low incidence, because the associated autoantibodies are directly pathogenic, their target protein is known, and the presence of foci of endemic disease suggests an infectious cause in at least one variant of the disorder. Since the clinical hallmark of pemphigus foliaceus is the disruption of the superficial part of the epidermis, the manifestations have been simple to monitor, and the responses to therapy easy to assess.Pemphigus (from the Greek pemphix, meaning bubble or blister) encompasses a group of autoimmune . . .