A Simple One-Pot Method for 6-Oxopurine Ribonucleoside Synthesis: Control and Mechanism of Isomer Distribution
- 1 January 1984
- journal article
- research article
- Published by Taylor & Francis in Nucleosides, Nucleotides and Nucleic Acids
- Vol. 3 (1) , 33-44
- https://doi.org/10.1080/07328318408079417
Abstract
Combination of bis(trimethylsilyl)acetamide as a silylating reagent and trimethylsilyl trifluoromethanesulfonate as a catalyst forms an exceptionally stable system for a facile one-pot preparation of 6-oxopurine ribonucleosides. The 7β isomer of the ribonucleosides, formed first, is converted into the 9β isomer presumably via the 7,9-diribonucleoside. The procedure affords both 7β and 9β isomers, but finally yields the 9β isomer as the main product.This publication has 11 references indexed in Scilit:
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