Erythro-5-[1-hydroxy-2-(isopropylamino)butyl]-7-hydroxycarbostyril, a terbutaline-type derivative of the bronchodilator procaterol
- 1 May 1981
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 24 (5) , 634-636
- https://doi.org/10.1021/jm00137a030
Abstract
Erythro-5-[1-Hydroxy-2-(isopropylamino)butyl]-7-hydroxycarbostyril (4), which is a terbutaline-type derivative of the bronchodilator procaterol, was synthesized by transfer of the 8-hydroxyl group of procaterol to the 7 position. Compound 4 showed less potent .beta.-adrenoceptor stimulant activities than procaterol or terbutaline in an in vitro test using guinea pig tracheal muscle and right atrium. In an in vivo assay on anesthetized dogs, compound 4 showed 42 times less bronchodilator activity and 87 times less effect on the heart rate than l-isoproterenol.This publication has 0 references indexed in Scilit: