HIGH FREE AND LATENT COLLAGENASE ACTIVITY IN PSORIATIC ARTHRITIS SYNOVIAL FLUIDS

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Abstract
Collagenase activity has been studied intensively in SF from OA and RA patients. Less is known about collagenolytic activity in PsA SF. Therefore we examined collagenolytic activity in crude and trypsin treated SF as well as the αl-antitrypsin and α2-macroglobulin concentrations in 50 patients suffering from OA (n = 13), RA (n = 17), and PsA (n = 20). Free collagenolytic activity was low in the crude OA SF (1.80 ± 1.35 μg released collagen/min/ml SF) and almost equally low in RA SF (2.35 ± 1.80 μg released collagen/min/ml SF; P>0.3). The PsA SF, however, exhibited a significantly higher free collagenolytic activity (5.63 ± 5.69 μg released collagen/min/ml SF; PP < 0.05). Concomitantly with the collagenolytic activity, the αl-antitrypsin and α2-macroglobulin concentrations of the SF were measured. In SF from patients with PsA (172.9 ± 69.4 mg/100 ml) and RA (190.6 ± 64.7 mg/100 ml) the αl-antitrypsin was significantly higher than in those from OA SF (106.1 ± 39.2 mg/100 ml). On the other hand the α2-macroglobulin concentration was significantly lower in PsA SF (70.5 ± 17.2 mg/100 ml) in comparison with OA (91.9 ± 323 mg/100 ml; P < 0.03) and RA (96.4 ± 35.0 mg/100 ml P < 0.05) SF. The results of the present study show that in contrast to RA and OA SF, PsA SF contain an unexpectedly high free collagenolytic activity which is significantly correlated with the low α2-macroglobulin concentration in these SF

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