THE INFLUENCE OF SOME OESTROGENS AND PROGESTOGENS ON THE ACTIVITY OF GLYCERYLPHOSPHORYLCHOLINE DIESTERASE IN RINSINGS OF THE RAT UTERUS

Abstract
SUMMARY: The effects of some oestrogens and progestogens on the glycerylphosphorylcholine (GPC) diesterase activity and the protein concentration of rinsings of the rat uterus have been studied in relation to changes in the weight of this organ. Both enzyme activity and protein concentration were increased by subcutaneous administration of oestradiol-3:17β, oestriol, oestrone and diethylstilboestrol to ovariectomized rats and these responses were inhibited by progesterone and 17α-ethyl-19-nortestosterone. The GPC diesterase activity and protein content of uterine rinsings were affected independently of each other and of changes in the uterine weight.