Free Radical-induced Cross-linking of Polydeoxythymidylic Acid in Deoxygenated Aqueous Solution
- 1 January 1985
- journal article
- review article
- Published by Taylor & Francis in International Journal of Radiation Biology
- Vol. 49 (1) , 67-75
- https://doi.org/10.1080/09553008514552241
Abstract
Radiation-generated hydroxyl radicals and hydrogen atoms were shown to induce the cross-linking of polydeoxythymidylic acid (mol. wt .apprx. 170000) in N2O-saturated aqueous solution. The irradiated samples were hydrolysed with formic acid and then analysed by high performance liquid chromatography. Products were isolated and subsequently characterized by capillary gas chromatography-mass spectrometry. The presence of previously described monomeric thymine products was also shown. Yields were determined and mechanisms of formation were described for the products.This publication has 12 references indexed in Scilit:
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