Echinocandins: a new class of antifungal
Top Cited Papers
Open Access
- 1 June 2002
- journal article
- review article
- Published by Oxford University Press (OUP) in Journal of Antimicrobial Chemotherapy
- Vol. 49 (6) , 889-891
- https://doi.org/10.1093/jac/dkf045
Abstract
The echinocandins represent the first new antifungal drug class introduced for more than 15 years. They inhibit the synthesis of β-d-glucan in fungal cell walls. Their strengths include low toxicity, rapid fungicidal activity against most isolates of Candida spp. and predictable favourable kinetics allowing once a day dosing. In addition to Candida spp., their inhibitory spectrum includes Aspergillus spp. and Pneumocystis carinii, but not Cryptococcus neoformans.Keywords
This publication has 0 references indexed in Scilit: