Saving the Nerve from Glaucoma: Memantine to Caspaces
- 1 January 1999
- journal article
- review article
- Published by Taylor & Francis in Seminars in Ophthalmology
- Vol. 14 (3) , 152-158
- https://doi.org/10.3109/08820539909061468
Abstract
Three recent discoveries regarding the pathophysiology of human glaucoma are that retinal ganglion cells die by apoptosis, that nitric oxide synthase levels are altered, and that glutamate is elevated in the vitreous. These findings provide encouraging new avenues for the development of neuroprotective strategies to alleviate ganglion cell loss and blindness that accompanies this disease. In this article, we discuss some of these data, as well as potential therapies that may arise from these findings.Keywords
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