Myxedema and ataxia

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Abstract
A patient with long-standing myxedema and ataxia was found at necropsy to have focal degeneration involving the cerebellar cortex, especially In the vermls. Granular, round bodies containing glycogen were found and designated as neural myxedema bodies. Only a few of these bodies were found in a similar patient who was not ataxic and none in 2 other cases of myxedema nor in 24 older persons without hypothyroid disease. Neural myxedema bodies are structures not previously described. The evidence suggests that they are altered corpora amylacea. If so, neural myxedema bodies are the 1st instance of alteration of cerebral amyloid bodies in disease. The relationship of these bodies to myxedema and other known conditions is discussed.

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