PROSTAGLANDIN AND NOREPINEPHRINE METABOLISM: EFFECT OF INDOMETHACIN ON PROSTAGLANDIN SYNTHESIS AND NOREPINEPHRINE TURNOVER RATE

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Abstract
Although inhibition of prostaglandin (PG) synthesis [which is accompanied by increasing norepinephrine (NE) release] has been suggested as a mechanism of ulcerogenic action of indomethacin (IDM), the exact mode of action is not established. It was of interest to determine whether inhibition of PG synthesis by IDM could be accompanied by an increase in NE turnover rate in the rat stomach. The results suggest that IDM, at a dose which produces considerable gastric ulceration, does not facilitate the release of NE from sympathetic nerve terminals in the stomach.