The Effect of Oxygen and Some Other Gases on the Radiation Sensitivity of Dry Trypsin

Publisher Website
Google Scholar
Abstract
The effect of oxygen on the radiosensitivity of dry trypsin was measured under a variety of conditions. A maximum increase of 2.6 was found, and at 15 mm pressure of oxygen the sensitivity was halfway between the anoxic and maximum radiosensitivities. The effect cannot be caused by reactive species formed directly in the gas. Other experiments ruled out the possibility that peroxides formed on one molecule by the action of radiation attacked a second molecule when the samples were redissolved for assay. The oxygen effect decreased both with increased dose rate and with physical size of sample, probably owing to decreased oxygen concentration within the samples during irradiation. Nitric oxide also enhances the radiosensitivity of dry trypsin, but to a lesser extent. Nitrous oxide produces no change in the magnitude of the oxygen effect.

This publication has 0 references indexed in Scilit: