Induction of 2H+/Me2+ Exchange in Rat-Liver Mitochondria

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Abstract
The time dependency of Ca2+ efflux from Ca2+‐loaded rat liver mitochondria has been investigated. The rate of ruthenium‐red‐insensitive Ca2+ efflux is continuously increased during the retention as a result of induction of an electroneutral H+/Ca2+ exchange system. The activation of the Ca2+ efflux pathway takes place under the constant value of the membrane potential and is accompanied by oxidation of mitochondrial pyridine nucleotides. It has also been found that the ruthenium‐red‐insensitive H+/Sr2+ exchange occurs in mitochondria during Sr2+‐induced oscillation of ion fluxes. The rate of H+/Sr2+ exchange is variable and depends on the stage of the oscillatory cycle.