Onset and Localization of Collagen Synthesis during Wound Healing in Open Rat Skin Wounds

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Abstract
Previous studies suggest that there is an intial lag or latent phase following wounding. During this 4-6 day period, there is very little collagen synthesis as judged by tensile strength measurements, light and electron microscopy, and changes in the specific activity of hydroxyproline. In the present study of a sensitive biochemical method was used to measure collagen synthesis during the intial phase of open wound repair in rat skin and a significant increase in collagen synthesis was detected as early as 24 h. Analysis of various wound components demonstrated that the early increased collagen synthesis was localized in the panniculus carnosis. Collagen synthesis continued to increase with the greatest activity occuring on day 7 and by day 11 had returned to normal skin levels. Collagen synthesis may begin by 24 h after wounding and the initial phase of wound repair may not be preceded by a lag phase.

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