MULTIPRED: a computational system for prediction of promiscuous HLA binding peptides
Open Access
- 1 July 2005
- journal article
- research article
- Published by Oxford University Press (OUP) in Nucleic Acids Research
- Vol. 33 (Web Server) , W172-W179
- https://doi.org/10.1093/nar/gki452
Abstract
MULTIPRED is a web-based computational system for the prediction of peptide binding to multiple molecules (proteins) belonging to human leukocyte antigens (HLA) class I A2, A3 and class II DR supertypes. It uses hidden Markov models and artificial neural network methods as predictive engines. A novel data representation method enables MULTIPRED to predict peptides that promiscuously bind multiple HLA alleles within one HLA supertype. Extensive testing was performed for validation of the prediction models. Testing results show that MULTIPRED is both sensitive and specific and it has good predictive ability (area under the receiver operating characteristic curve AROC > 0.80). MULTIPRED can be used for the mapping of promiscuous T-cell epitopes as well as the regions of high concentration of these targets—termed T-cell epitope hotspots. MULTIPRED is available at http://antigen.i2r.a-star.edu.sg/multipred/.Keywords
This publication has 24 references indexed in Scilit:
- NEURAL MODELS FOR PREDICTING VIRAL VACCINE TARGETSJournal of Bioinformatics and Computational Biology, 2005
- Genome-wide Characterization of a Viral Cytotoxic T Lymphocyte Epitope RepertoireJournal of Biological Chemistry, 2003
- Sensitive quantitative predictions of peptide‐MHC binding by a ‘Query by Committee’ artificial neural network approachTissue Antigens, 2003
- Examining the independent binding assumption for binding of peptide epitopes to MHC-I moleculesBioinformatics, 2003
- Prediction of MHC class I binding peptides, using SVMHCBMC Bioinformatics, 2002
- Prediction of MHC class I binding peptides using profile motifsHuman Immunology, 2002
- Prediction of promiscuous peptides that bind HLA class I moleculesImmunology & Cell Biology, 2002
- Cut and trim: generating MHC class I peptide ligandsCurrent Opinion in Immunology, 2001
- Proteases involved in MHC dass II antigen presentationImmunological Reviews, 1999
- Nine major HLA class I supertypes account for the vast preponderance of HLA-A and -B polymorphismImmunogenetics, 1999