POTENCY AND DURATION OF ACTION OF TRIIODOTHYRONINE AND THYROXINE IN RATS AND MICE

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Abstract
Potency and duration of action of L-triiodothyronine and of DL-thyroxine were compared by determining their effects on the release of I131 from the thyroid in rats and on the sensitivity to anoxia in mice. Triiodothyronine appeared to be from 5 to 10 times as active as DL-thyroxine by each method. No significant difference in latent period or duration of action was shown in mice following single injections and tested over a period of 72 hours. DL-thyroxine appeared to exert a more prolonged effect than triiodothyronine in suppressing the release of I131 from the thyroid in rats when doses of similar potency were compared.

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