EFFECT OF DOPAMINE ON INTRAOCULAR-PRESSURE AND PUPIL OF RABBIT EYE

  • 1 January 1976
    • journal article
    • research article
    • Vol. 15  (5) , 371-380
Abstract
The presence of a dopamine-specific receptor that could influence intraocular pressure [IOP] in the rabbit eye was suggested by these experiments. Intravitreal, systemic or topically administered dopamine solutions produced a decrease in IOP that was dose-dependent. In high doses the decrease in IOP was accompanied by mydriasis, an .alpha.-adrenergic pupillary response. This .alpha.-response may be caused by dopamine as a direct but weak .alpha.-stimulator or by displacement of norepinephrine onto the receptor from its storage site. At lower doses the decrease in IOP occurred in the absence of mydriasis and despite blockade of .beta.-adrenergic receptors. A specific dopaminergic blocker, haloperidol, prevented this decrease in IOP. The decreases were small but reproducible and suggest that dopamine can influence the adrenergic regulation of IOP.

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