USE OF SERIAL DETERMINATION OF BLOOD-SERUM GLYCOPROTEINS FOR INDIRECT EVIDENCE OF SENSITIVITY AND RESISTANCE OF MALIGNANT-TUMOR CELLS TO CLINICAL CHEMOTHERAPY

  • 1 January 1977
    • journal article
    • research article
    • Vol. 24  (1) , 101-107
Abstract
Sialic acid and mucoprotein tyrosine (MPT) as 2 important and sensitive indicators of serum glycoprotein changes were used for the dynamic follow up of the tumor growth in humans. Their determination was performed before and during chemotherapy with the aim to evaluate indirectly the sensitivity or resistance of malignant cell to chemotherapy. Sixteen cases with gynecological malignancies were investigated. According to the results of laboratory findings the patients were divided into 3 groups: decreased values after chemotherapy, no change or increased values, and uncertain results. The laboratory findings corresponded well with the clinical course of the disease.

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