The Mechanisms of Peroxynitrite-Induced Relaxations in Isolated Rat Anococcygeus Muscle

7 August 2002

journal article
research article
Published by S. Karger AG in Pharmacology

Vol. 66 (1) , 1-4
https://doi.org/10.1159/000065311

Abstract

We have previously reported that peroxynitrite (ONOO^–) caused relaxations on isolated rat anococcygeus muscle and in the present study the possible mechanisms of the relaxant effect were investigated. ONOO^– (0.03– 1.0 mmol/l)-induced relaxations were reduced significantly by the presence of an ATP-sensitive potassium channel (K⁺_ATP channel) blocker, glibenclamide (0.3 µmol/l), or 1H-(1,2,4)oxadiazolo(4,3-α)quinoxalin-1-one (ODQ) (30.0 µmol/l), a guanylyl cyclase inhibitor. However, 3-aminobenzamide (3.0 mmol/l), an inhibitor of poly(ADP- ribose)synthase, did not influence the relaxant effect of ONOO^– (1.0 mmol/l). Results of the present study implicate that activation of K⁺_ATP channels and/or cGMP/K⁺_ATP channel interaction might play a role in the relaxant responses to ONOO^– in isolated rat anococcygeus muscle.

Keywords

This publication has 1 reference indexed in Scilit:

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