The Response of Prostatic Fluid pH in Inflammation

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Abstract
Summary: Expressed prostatic secretion (EPS) was obtained both from the uninflamed human prostate and from cases of acute and subacute prostatitis in the course of routine clinical examination. In addition to microscopy and bacteriological examination, the pH of this fluid was tested using both Camlab Duotest pH papers (Camlab Ltd, Cambridge) and a Radiometer pH Micro‐electrode.Specimens of EPS from the normal gland were found to have a mean pH of 6.6 and were therefore similar in this respect to normal canine prostatic fluid. In a series of specimens from cases of prostatitis, there was a variable increase in pH, the mean being 7.7.The implications of this finding are briefly discussed in relationship to the concentration of antibacterial agents within the prostatic acini and ducts and their biological activity.Part of the work of this project was assisted by a grant from Schering Chemicals Ltd, England.

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