Insulin and the Stimulation of Glycogen Synthesis. The Road from Glycogen Structure to Glycogen Synthase to Cyclic Amp‐Dependent Protein Kinase to Insulin Mediators
- 1 January 1990
- book chapter
- Published by Wiley
- Vol. 63, 173-231
- https://doi.org/10.1002/9780470123096.ch3
Abstract
This chapter contains sections titled: Introduction Historical Biochemical Considerations and a Glycogen‐K+ Pump Hypothesis Integration of Covalent and Allosteric Controls of Phosphorylase and Glycogen Synthase Phosphorylation Sites of Glycogen Synthase Emerging Significance of Multiple Phosphorylation Decreased Phosphorylation of Glycogen Synthase with Insulin Action Insulin and Established Second Messengers Stable and Allosteric Effects of Insulin on Protein Kinases Short‐ and Long‐Term Effects of Insulin on Phosphoprotein Phosphatases Two Pathways for Activation of Glycogen Synthase by Insulin Purification and Action of Two Mediators‐A Mechanism for Dephosphory lation Formation of lnsulin Mediators Insulin Receptor Activation and Mediator Formation SummaryKeywords
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