AnIn vitroStudy of Ileal Colonisation Resistance toEscherichia coliStrain Bd 1107/75 08 (K88) in Relation to Indigenous Squamous Gastric Colonisation in Piglets of Varying Ages

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Abstract
Ileal colonisation resistance to Escherichia coli strain Bd 1107/75 08 (K88) in piglets aged 5, 26 and 47 days and the possible relation to indigenous gastric colonisation was studied. In diluted ileal extracts, heat labile growth inhibitory activity was detected. At 26 d, the in vitro adhesion of K88 fimbriae on E.coli to ileal mucus was markedly increased, while the level of in vitro adhesion of Lactobacillus crispatus strain 152 to stomach tissue pieces decreased. In addition, scanning electron microscopy revealed that the composition of the squamous stomach epithelium associated flora changed dramatically at this time. From these results, it appears that age and consequently related factors influence the ileal colonisation resistance to E.coli strain Bd 1107/75 08 (K88) and the composition of the squamous indigenous gastric flora.