Copper-Catalyzed Etherification of Aryl Iodides Using KF/Al2O3: An Improved Protocol
- 14 April 2005
- journal article
- letter
- Published by Georg Thieme Verlag KG in Synlett
- Vol. 2005 (7) , 1101-1104
- https://doi.org/10.1055/s-2005-865198
Abstract
A simple and efficient method for the coupling of aryl iodides with aliphatic alcohols and phenols that does not require the use of alkoxide bases is described. This C-O bond forming procedure shows that the combination of air stable CuI and 1,10-phenanthroline in the presence of KF/Al2O3 comprises an extremely efficient and general catalyst system for the etherification of aryl iodides. Different functionalized aryl iodides were coupled with alcohols and phenols using this method.Keywords
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