THE AMNESIC EFFECT OF DIAZEPAM (VALIUM)

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Abstract
A double-blind trial of intravenous diazepam (0.24 mg/kg) versus saline was carried out on twelve young intelligent male volunteers to examine the amnesic effect of the drug. Complex psychological testing extended over a 2-hour period. Dense anterograde amnesia was found for approximately 10 minutes with a less severe impairment of memory persisting at least half an hour after injection. It is considered that the memory difficulties were not due to serious reduction of level of consciousness but do focus on the input or “consolidation” processes rather than on retrieval. Further studies are needed to define more clearly the nature of the deficit.

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