Studies on Bone Marrow Lipid in Normal and Irradiated Rabbits

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Abstract
Rabbit bone marrow homogenates, unlike those of liver, kidney, and brain, do not produce fatty acid peroxides when incubated in vitro. Marrow extracts inhibit peroxides. This effect is apparently dependent on the sulfhydryl content of the extract. Forty-eight hours after exposure of the rabbit to 1400 r, marrow homogenates produce peroxides when incubated in vitro. They also have measurable amounts of peroxides in the fat fraction before incubation. Extracts from rabbits exposed to 800 r are less effective than normal ones in protecting the succinoxidase against peroxides. There was a significant increase in linoleic, linolenic, and total fat in the marrow of the irradiated animals. Vitamins K, A, and E inhibit peroxide formation in liver homogenates but do not protect succinoxidase against inhibition by peroxides.