The biochemistry and physiology of glucuronic acid

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Abstract
IV. A brief summary including new observations is given of the normal occurrence of glucuronic acid in the blood and urine of various animals. A stereochemical study of the conjugation of d- and l-borneol with glucuronic acid in dogs reveals a preferential conjugation of the d-isomeride.[long dash]V. By a new technic for perfusing various canine organs such as the liver, spleen, and the tissues of the hind limb, in combination with the kidney, it is demonstrated that the liver is the main, and probably the only, site of formation and conjugation of glucuronic acid formed in response to phenol, chloral hydrate, camphor and borneol. The process of conjugation in the liver is abolished by cyanide. [beta]-Bornyl- and [beta]-phenyl-d-glucosides are not converted to the corresponding glucuronides (conjugated glucuronic acids) when perfused through the combined liver-kidney preparation and no support is therefore found for the hypothesis that the production of the glucoside is an intermediate stage in glucuronide formation.

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