COMPARISONS OF ANTIDOTAL EFFICACY OF CHELATING DRUGS UPON ACUTE TOXICITY OF NI(II) IN RATS
- 1 January 1976
- journal article
- research article
- Vol. 14 (1) , 153-165
Abstract
Six chelating drugs were administered to rats by i.m. injection at equimolar dosages in order to compare their relative effectiveness in prevention of death after a single parenteral injection of NiCl2. Triethylenetetramine and d-penicillamine were the most effective antidotes for acute Ni(II)-toxicity. In order of decreasing antidotal effectiveness, diglycyl-L-histidine-N-methylamide, sodium diethyldithiocarbamate and calcium disodium versenate significantly reduced the acute mortality of rats following i.p. injection of Ni(II). .alpha.-Lipoic acid was not effective as an antidote for acute Ni(II)-toxicity.This publication has 5 references indexed in Scilit:
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