The synthesis of terminal enynes by Grignard additions to pyridazine 1-oxide
- 1 January 1979
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- No. 9,p. 2136-2137
- https://doi.org/10.1039/p19790002136
Abstract
The ring opening of pyridazine 1 -oxide by the Grignard reagents prepared from 3-bromochlorobenzene, bromobenzene, 1 -bromonaphthalene, pent-1 -yne, and 1 -phenylbut-1 -en-3-yne is shown to lead exclusively to the corresponding terminal E-enynes (3a), (3b), (5), (6), and (7) respectively. By contrast, alkyl Grignard reagents instead lead to the corresponding 1, 3-dienes (9).This publication has 1 reference indexed in Scilit:
- Marine natural products: isodactylyne, a halogenated acetylenic ether from the sea hare Aplysia dactylomelaThe Journal of Organic Chemistry, 1976