THE LACK OF EFFECT OF THE ADRENAL HORMONES UPON GASTRIC ACID SECRETION1

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Abstract
TUERKISHER and Wertheimer (1945) found that the secretion of free and total acid by the stomachs of adrenalectomized, anesthetized and laparotomized rats was lower than that in control rats. Acid secretion in their preparations was not increased by administration of sodium chloride or desoxycorticosterone acetate, but it was increased by injections of a whole extract of the adrenal cortex. They concluded that the presence of hormones of the adrenal cortex is essential for the secretion of acid by the stomach. Many of the numerous physiological changes which occur in animals as the result of adrenalectomy are known to affect the ability of the stomach to secrete acid. Among these changes are a fall in blood pressure and cardiac output, a decrease in blood glucose concentration, a distortion of the plasma electrolyte pattern and the occurrence of acidosis. It is possible that the failure of the stomach to secrete acid

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