ANTIBODIES AGAINST PSEUDOMONAS-AERUGINOSA IN SERUM FROM NORMAL PERSONS AND PATIENTS COLONIZED WITH MUCOID OR NON-MUCOID PSEUDOMONAS-AERUGINOSA - RESULTS OBTAINED BY CROSSED IMMUNOELECTROPHORESIS

  • 1 January 1977
    • journal article
    • research article
    • Vol. 85  (2) , 142-148
Abstract
Serum from 154 normal persons was investigated for precipitating antibodies against P. aeruginosa by crossed immunoelectrophoresis, using a polyvalent P. aeruginosa standard antigen. Of the sera, 94% contained no demonstrable precipitins and 6% contained precipitins against only 1 P. aeruginosa antigen. Of the sera from 122 patients colonized with P. aeruginosa in various anatomical regions, 34% contained precipitins against 2-41 P. aeruginosa antigens. Serum from 14 patients harboring mucoid strains of P. aeruginosa contained precipitins against these bacteria; the average number of precipitins was significantly higher than the average number of precipitins in serum from patients harboring non-mucoid strains. The largest number of precipitins was found in serum from adult patients chronically colonized with mucoid P. aeruginosa in the lower respiratory tract, and from adult patients with P. aeruginosa bacteremia originating from suppurative urinary tract infections caused by mucoid strains. Serum from patients with P. aeruginosa cystitis, or from patients with P. aeruginosa colonization of the middle ear or with wound infection, contained only few or no precipitins.

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