COMPARATIVE STUDY OF LIQUID AND FREEZE-DRIED GLUTAMATE BCG - RESULTS OF A FIELD TRIAL IN WEST PAPUA (NETHERLANDS NEW GUINEA)

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Abstract
Data are presented on a comparative BCG vaccination trial, using liquid BCG Copenhagen and Japanese freeze-dried glutamate BCG. The conversion to 1 TU RT 23/0.1 ml with Tween was measured at intervals of approximately 7 weeks. The total observation period was 46 weeks. Studies on the viability of the vaccine, after transportation to and from the field station, were included in the study and demonstrated that the vaccine actually injected contained large numbers of viable units. The conversion after vaccination with freeze-dried glutamate BCG was not inferior to the conversion after vaccination with liquid BCG. Vaccination lesions in people vaccinated with freeze-dried glutamate BCG were somewhat slower to develop into a scar, and the ultimate scar was also larger in freeze-dried than in liquid BCG-vaccinated persons. On the basis of the present study, glutamate BCG will replace the formerly used liquid vaccine in all mass vaccination campaigns in the territory.

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