Photodynamic therapy of tumours with hexadecafluoro zinc phthalocyanine formulated in PEG-coated poly(lactic acid) nanoparticles
Open Access
- 11 June 1996
- journal article
- research article
- Published by Wiley in International Journal of Cancer
- Vol. 66 (6) , 821-824
- https://doi.org/10.1002/(sici)1097-0215(19960611)66:6<821::aid-ijc19>3.0.co;2-5
Abstract
Hexadecafluoro zinc phthalocyanine (ZnPcF16), a second‐generation sensitizer for the photodynamic therapy (PDT) of cancer, was formulated in polyethylene‐glycol‐coated poly(lactic acid) nanoparticles (PEG‐coated PLA‐NP) and tested in EMT‐6 tumour‐bearing mice for its photodynamic activity. The tumour response was compared to that induced by the same dye formulated as a Cremophor EL (CRM) emulsion. Formulation in the biodegradable NP improved PDT response of the tumour while providing prolonged tumour sensitivity towards PDT. © 1996 Wiley‐Liss, Inc.Keywords
This publication has 13 references indexed in Scilit:
- PEG-coated Poly(lactic acid) Nanoparticles for the Delivery of Hexadecafluoro Zinc Phthalocyanine to EMT-6 Mouse Mammary TumoursJournal of Pharmacy and Pharmacology, 1995
- Pharmacokinetics and Body Distribution of Liposomal Zinc Phthalocyanine in Tumor‐Bearing Mice: Influence of Aggregation State, Particle Size, and CompositionJournal of Pharmaceutical Sciences, 1995
- Large‐Scale Production of Liposomes Containing Monomeric Zinc Phthalocyanine by Controlled Dilution of Organic SolventsJournal of Pharmaceutical Sciences, 1994
- Internalization of poly(D,L‐1actic acid) nanoparticles by isolated human leukocytes and analysis of plasma proteins adsorbed onto the particlesJournal of Biomedical Materials Research, 1994
- Synthesis and Photodynamic Activities of Silicon 2,3-Naphthalocyanine DerivativesJournal of Medicinal Chemistry, 1994
- Microspheres for targeting drugs to specific body sitesJournal of Controlled Release, 1993
- Preparation of aqueous polymeric nanodispersions by a reversible salting-out process: influence of process parameters on particle sizeInternational Journal of Pharmaceutics, 1992
- HOW DOES PHOTODYNAMIC THERAPY WORK?Photochemistry and Photobiology, 1992
- PHTHALOCYANINES AS PHOTODYNAMIC SENSITIZERS*Photochemistry and Photobiology, 1991
- Delivery of the tumour photosensitizer zinc(II)-phthalocyanine to serum proteins by different liposomes: studies in vitro and in vivoCancer Letters, 1990